The Oral Administration of Elastin Peptide Reduces Ultraviolet Light-Induced Photoaging in Hairless Mice
Zheng Yan1,2,*, Shuang Liu2, Ai-Qing Liu2 and Hai-Yan Wang2
1College of Bioengineering, Beijing Ρolytechnic, Beijing 100176, China
2Beijing Semnl Biotechnology Co., Ltd., Beijing 100062, China
https://dx.doi.org/10.17582/journal.pjz/20200629020649
Fig. 1.
Effect of elastin peptide on elasticity of skin of UV induced photoaged hairless mice. A, Q1 = total elastic – plastic area of the spring – back component; B, R2 = total elastic – plastic amount of the rebound component. For comparisons between UV-irradiated controls and experimental groups. *, P< 0.05; **, P< 0.01; ***, P<0.001.
Fig. 2.
Effect of elastin peptide on collagen content of skin of UV induced photoaging hairless mice. A, Col-I; B, Col-III; C, Col-IV. For comparisons between UV-irradiated controls and experimental groups. *, P< 0.05; **, P< 0.01; ***, P<0.001.
Fig. 3.
Effect of elastin peptide on hydroxyproline (Hyp) content of skin of UV induced photoaging hairless mice. For comparisons between UV-irradiated controls and experimental groups. **, P< 0.01; ***, P<0.001.
Fig. 4.
Effect of elastin peptide on hyaluronic acid (HA) content of skin of UV induced photoaging hairless mice. For comparisons between UV-irradiated controls and experimental groups. ***, P<0.001.
Fig. 5.
Effect of elastin peptide on dorsal tissues of skin of UV induced photoaging hairless mice. A, normal group; B, UV induced group; C, low-dose group; D, middle-dose group; E, high-dose group. Staining, H&E; Magnification, ×400.