Selenium Synergize Levothyroxine in Restoring Leukocytes Cluster Differentiation Expression in Methimazole Induced Hypothyroidism
Selenium Synergize Levothyroxine in Restoring Leukocytes Cluster Differentiation Expression in Methimazole Induced Hypothyroidism
Aryaf Mahmood Sabea1*, Majida A. Al-Qaiym2
ABSTRACT
Thyroid hormones and selenium has been shown to play essential role in immune system, however the impact of hypothyroidism in immune cells and its relationship with selenium supplement in vivo has not well explored. Accordingly the present study designed to elucidate role of selenium in immunosuppression of hypothyroidism rats. Forty four female Wister rats of 3-4 months aged were equally and randomly divided into 5 groups except the control, which contains 8 rats. The 2nd, 3rd, 4th, and 5th groups were subjected to hypothyroidism by oral intubation of 0.02% Methimazole daily for 4 weeks. Treatments of 3rd with Sc-SeNPs (0.1mg selenium /kg/ day) as T1, 4th with Levothyroxine (0.9 µg/100g BW/day) as T2, 5th with SC-SeNPs (0.1mg selenium /kg/ day)+ Levothyroxine (0.9 µg/100g BW/day) as T3, in addition to 2nd hypothyroidism untreated group for 4weeks. Immunohistochemistry analysis showed that expression of CD4, CD8, and CD19 on Tand B lymphocytes and CD68 on macrophages were affected inversely by hypothyroidism. Selenium supplementation synergies levothyroxine in reestablishment the activity of lymphocytes and macrophages. In conclusion, the present study demonstrated that thyroid hormones had regulatory role for innate and adaptive, and in order to reach the best result of treating hypothyroidism and improving the activity of the immune cells , selenium must be given with the Levothyroxine
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