Water shortage should be intimidating issue for agriculture crops. Adaptation of modern techniques and management practices in oil seed crops can reduce water shortage risks with optimum yield in oil seed crops. Sesame is being considered the most tolerant crop for avoiding drought conditions with higher yield. Experiments on “response of sesame to sowing methods, nitrogen and sulphur levels” were carried out in Agronomy Research Farms, The University of Agriculture, Peshawar. During two consecutive Kharif growing seasons of 2013 and 2014, respectively. Three sowing methods (flat, ridges and raised bed) were kept as main plot factor, whereas four nitrogen levels (00, 60, 120, and 180 kg ha-1) and four treatments of sulphur (00, 20, 30 and 40 kg ha-1), were kept as sub plot factors, which were replicated four time for each experiment. Urea and ammonium sulphate fertilizers were used as a source of nitrogen and sulfur nutrients. Results showed that all quantitative and qualitative parameters of sesame had significantly influenced by year. Study showed that raised bed sown plots significantly (p ≤ 0.05) produced more: leaves plant-1 (243), leaves area plant-1(444.35cm2), branchesplant-1(9), plant height (198.51cm), and seed yield (1339kg ha-1), were recorded as compared with other sowing methods. It was also resulted from findings that N (180 kg ha-1) had significantly delayed flower and pod formation (7 and 9days) respectively as compared with control plots. Higher: leaves plant-1 (242), leaves area plant-1(492.79cm2), branches plant-1 (9), plant height (212.56cm), and seed yield (1581kg ha-1). Sulphur applied at 40 kg S ha-1 had significantly produced more: leaves area plant-1(446.14cm2), plant height (192.25cm), and seed yield (1346kg ha-1), as compared with lower levels of sulphur. Interactive response of NxS and NxSxSM, were found significant for leaves area plant-1, plant height and seed yield. It is concluded that sowing sesame on raised bed and followed by ridges sowing method, with combined application of 180 kg N ha-1 and 40 kg S ha-1 produced higher yield and yield related components.