Radiological Evaluation Of Acellular Fish Swim Bladder and Autologous Bone Marrow Clot on Induced Radial Bone Defects in Rabbits
Radiological Evaluation Of Acellular Fish Swim Bladder and Autologous Bone Marrow Clot on Induced Radial Bone Defects in Rabbits
Noorulhuda A. Mahdi, Nadia H.R. AL-Falahi*
ABSTRACT
The defect in segmental bone was commonly required a surgical intervention for restoration bone function. Fifteen healthy adult rabbits with 9-12 months old and weighted 1.5-1.7 Kg. were divided equally into three groups (n=5), in all animals the segmental defects of 5mm were induced in the midshaft of the radius, the first group was induced segmental defect and untreated (control group) , the second group was created defects, wrapped using the previously prepared a cellular fish swim bladder (FSB) and sutured around the bone defects (FSB group), while the third group was created defects, wrapped using FSB as previously described after filling the bone defect with clotted autologous bone marrow (FSB-BMC group). The segmental defects in all groups were evaluated radiographically immediately after operation then every two weeks till 12 weeks post operation to observe the bone formation and bridging of segmental bone defects. The results indicated a new bone formation and mineralization on radiographs in both treated groups at 4th week post operation, a partially bridging of the segmental defect in a straight direction in the FSB group was seen at 12th week post operation , while a complete bridging in a straight direction in the FSB-BMC group was observed radiographically from 8th week and continued to 12th week post operation when compared to control group in which the new bone formation was sloped to the center of the defect at 6th week post operation with higher bony connection between radius and ulna at 12th week post operation. From this study concluded the combination between FSB membrane as guided bone regeneration and bone marrow clot had a good osteoinduction properties in segmental bone defects regeneration.
Keywords | Segmental bone defect, Fish swim bladder, Bone marrow clot, Guided bone regeneration, Rabbits
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