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Predominance of Macular Corneal Dystrophy in Lahore Population

Predominance of Macular Corneal Dystrophy in Lahore Population

Shagufta Naz*, Saima Sharif, Hafsa Badar, Syeda Fareeha Tauheed

Department of Zoology, Lahore College for Women University Lahore, Pakistan.

*Corresponding author: Shagufta Naz, shagufta829@hotmail.com

 

ABSTRACT

Macular corneal dystrophy (MCD), an autosomal recessive hereditary disease, slowly progresses punctate opacities in the cornea which result in bilateral loss of vision and leads to corneal transplantation. A cross-sectional, analytical study was carried out from August, 2015 to May, 2016 on and MCD patients were diagnosed by visiting different hospitals like, General Hospital, Al-Ehsan welfare Hospital, Mughal eye and Mayo Hospital with the help of ophthalmologist. The main purpose of such type of research was directed to find the prevalence of Macular corneal dystrophy in the families of Lahore. The techniques used for the diagnosis of MCD were visual Acuity test by Snellen chart, phoropter, slit lamp biomicroscopy, topography, keratometer and pachymetry. In this study, 50 patients of MCD were identified among which 40 were males and 10 were females, including 9 cases with family history. Main complaint was drop in visual acuity and loss of vision in all patients (100%) due to damage and accumulation ofkeratan sulfate (KS) in macular layer of corneal stroma. 87% cases have high vision loss and 13% patients have moderate vision loss. MCD were bilateral in all cases (100%). Cases of MCD were observed in all age groups but 40% cases were found in age 21-30 years. IOP was found to be normal in most of the cases and also increases as age increases. Corneal thickness was decreased in 73.8% cases due to accumulation in corneal stroma. Careful clinical evaluation, early diagnosis, genotyping, genetic counseling and proper treatment (corneal grafting) are necessary for the restoration of optimal vision and should be done to avoid the severe outcomes caused by MCD.
 

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Punjab University Journal of Zoology

December

Vol. 35, Iss. 2, pp. 167-268

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