Possible Role of Neuromedin S (NMS) in Male Reproduction: Effect of NMS on Adipokines Secretion in Male Rhesus Monkeys (Macaca mulatta)
Possible Role of Neuromedin S (NMS) in Male Reproduction: Effect of NMS on Adipokines Secretion in Male Rhesus Monkeys (Macaca mulatta)
Shakeel Ahmed* and Sarwat Jahan
ABSTRACT
Adipokines are known as important adiposity signals and play certain roles in various biological processes. Now their involvement in the regulation of hypothalamus pituitary gonadal (HPG) axis has also been established. In the present study, we investigated the role of peripheral administration of neuromedin S (NMS) on adipokines (adiponectin, leptin and resistin) secretion in 48-h fasting and normal fed adult male Rhesus monkeys. After NMS administration plasma adipokines levels were determined in fed and fasting monkeys. Four intact adult male monkeys were used in this study. 50 nmol of NMS was injected intravenously. Blood samples were collected individually 60 min before and 120 min after NMS administration at 15 min intervals. The plasma adipokines concentrations were determined by using specific Enzyme Immunoassay (EIA) kits. 48 h fasting significantly increased plasma adiponectin (P<0.001), while decreased leptin (P<0.001) and resistin (P<0.01) concentrations compared to normal fed monkeys. No significant (P>0.05) change in adiponectin levels was observed after NMS injection in both normal and metabolically stressed conditions. NMS administration induced a significant (P<0.01) increase in resistin levels, while suppressed leptin (P<0.05) secretion in both fed and 48-hrs fasting conditions. In conclusion our study suggested that NMS has a role in regulation of adipokines secretion. Its inhibitory effect on leptin and stimulatory effect on resistin shows an important relationship between NMS and adipokines in the regulation of reproductive axis in male rhesus monkeys. Further studies are required to confirm this relationship.
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