Phytochemical and Toxicological Studies of Methanolic Extract of Lemon Verbena in Hamsters
Phytochemical and Toxicological Studies of Methanolic Extract of Lemon Verbena in Hamsters
Oumaima Abouyaala, Soukaina Bougrine, Mohamed Yassine El Brouzi*, Radia Elgui, Sara Brikat, Khadija Elmotia, Abdelhalem Mesfioui, Aboubaker El-Hessni, Moulay Laarbi Ouahidi
Variation in body weight during subacute toxicity of MELV at different doses in female (a) and male (b) hamster. The results are represented by the mean ± SD (n = 6); significance levels were indicated as: * P <0.05; ** P <0.01; *** P <0.001.
Variation in relative liver (a) and kidney (b) weights of the different groups treated with MELV in both sexe. The results are represented by the mean ± SD (n = 6); significance levels were indicated as: * P <0.05; ** P <0.01; *** P <0.001.
Effect of MELV on blood glucose levels; Gly (glycemia), on Lipid profile; serum total cholesterol (Chol) and triglycerides (TG) levels, on renal function; serum urea and creatinine (crea), also, on hepatic function; serum aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) levels in subacute toxicity in both sex hamsters. The results are represented by the mean ± SD (n = 6); significance levels were indicated as: * P <0.05; ** P <0.01; *** P <0.001.
Catalase activity in liver (a) and kidney (b) in Male and female hamsters treated with different doses of MELV and control. The results are represented by the mean ± SD (n = 6); significance levels were indicated as: * P <0.05; ** P <0.01; *** P <0.001.
No level in liver (a) and kidney (b) in Male and female hamsters treated with different doses of MELV and control. The results are represented by the mean ± SD (n = 6); significance levels were indicated as: * P <0.05; ** P <0.01; *** P <0.001.
Effect of different doses of MELV (125. 250 and 500 mg/kg bw) on histological section of liver and kidney tissue in male and female hamsters. (Black arrow) Moderate hepatic necrosis, (+) periportal lymphocyte infiltrate, (Red arrow) predominantly lymphocyte glomerular infiltrate, (Green arrow) sinusoidal dilatation, (Blue arrow) tubular atrophy.
