Physiological Effect of Glycyrrhizic Acid on Adrenal Insufficiency Induces by Glucocorticoid in Rats
Physiological Effect of Glycyrrhizic Acid on Adrenal Insufficiency Induces by Glucocorticoid in Rats
Wafaa AL. Bnyean1,2 ,Zainab A.H. AL-Mousawi1*
ABSTRACT
This study investigates the efficacy of Glycyrrhizic acid (GA) against adrenal insufficiency caused by glucocorticoids in female rats. Fifty female rats were divided randomly into five groups. Negative control group(G1): Normal saline was given orally to rats. Positive control group(G2): rats for seven days were treated with Hydrocortisone Sodium I.P. (50 mg/kg). Therapeutic group(G3): rats for seven days were treated with Hydrocortisone Sodium I.P. (50 mg/kg) and then 14 days with GA (100 mg /kg) orally. Protective group(G4): Rats were treated for seven days with hydrocortisone Sodium I.P. (50 mg /kg) with GA for 14 days(100mg/kg) orally. glycyrrhizic acid Group (G 5): rats for 21 days, were given 100 mg/kg of GA orally. At the end of the experiment, Serum cortisol, ACTH, CRH hormone, 11 β -Hydroxysteroid Dehydrogenase enzyme (11β-HSD), and malondialdehyde were measured. The results revealed treatment with glycyrrhizic acid improved significantly (P<0.05) in serum cortisol, ACTH, CRH hormones, and (11β-HSD) enzyme concentration, while was a significant reduction in serum MDA level in the therapeutic and protective group compared with the positive control group. Our results concluded that glycyrrhizic acid improves the alteration caused by hydrocortisone of hypothalamus pituitary adrenal axis hormones and reduces the free radicals.
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