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Physiological Effect of Glycyrrhizic Acid on Adrenal Insufficiency Induces by Glucocorticoid in Rats

Physiological Effect of Glycyrrhizic Acid on Adrenal Insufficiency Induces by Glucocorticoid in Rats

Wafaa AL. Bnyean1,2 ,Zainab A.H. AL-Mousawi1* 

1Department of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Basrah, Iraq; 2Institute of Medical Technology of Baghdad, Middle Technical University, Iraq.

*Correspondence | Zainab A.H. Al-Mousawi, Department of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Basrah, Iraq; Email: [email protected].

Figure 1

Effect of Glycyrrhizic acid on serum cortisol, ACTH, and CRH Concentration in adrenal insufficiency in rats. Control negative: received normal saline, control positive: hydrocortisone, Therapeutic: received hydrocortisone then Glycyrrhizic acid, Protective: received hydrocortisone with Glycyrrhizic acid, Glycyrrhizic Acid: Glycyrrhizic acid only. 

Figure 2

Effect of Glycyrrhizic Acid on 11 β -Hydroxysteroid Dehydrogenase Enzyme in Adrenal Insufficiency Female Rats. Control negative: received normal saline, control positive: hydrocortisone, Therapeutic: received hydrocortisone then Glycyrrhizic acid, Protective: received hydrocortisone with Glycyrrhizic acid, Glycyrrhizic Acid: Glycyrrhizic acid only. 

Figure 3

Effect of Glycyrrhizic Acid on MDA, concentration in Adrenal Insufficiency Female Rats. Control negative: received normal saline, control positive: hydrocortisone, Therapeutic: received hydrocortisone then Glycyrrhizic acid, Protective: received hydrocortisone with Glycyrrhizic acid, Glycyrrhizic Acid: Glycyrrhizic acid only. 

Advances in Animal and Veterinary Sciences

November

Vol. 12, Iss. 11, pp. 2062-2300

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