Mechanisms of Bushen Zhuyun Decoction Regulating Pituitary Cell GnRH Receptor and Downstream cAMP-PKA Signaling Pathway in Treating Infertility Due to Luteal Phase Defect
Mechanisms of Bushen Zhuyun Decoction Regulating Pituitary Cell GnRH Receptor and Downstream cAMP-PKA Signaling Pathway in Treating Infertility Due to Luteal Phase Defect
Bei Liu1, Yanli Hong1, Huifang Zhou1,*, Zhenzhen Cao1, Shuang Zhang1, Jing Jin1, Miao Jiang1, Cunsi Shen2 and Jianjian Ji2
Fig. 1.
Comparison of mRNA and protein levels of GnRHR in RPC cells. A, mRNA levels of GnRHR in RPC cells; B, protein levels of GnRHR in RPC cells. *p<0.05 conpared to the blank group, #p<0.05 compared to the model-treated group.
Fig. 2.
Comparison of mRNA and protein levels of PKA in RPC cells. *p<0.05 compared to the blank(-) group, #p<0.05,*p>0.05 compared to the Cetrorelix(-) group. &p<0.05 compared to the blank(+) group, ##p>0.05 compared to the Cetrorelix(+) group.
Fig. 3.
Comparison of mRNA and protein levels of CREB and Egr-1 in RPC cells. *p<0.05 compared to the blank(-) group, #p<0.05, *p>0.05 compared to the Cetrorelix (-) group. &p<0.05 compared to the blank(+) group,##p>0.05 compared to the Cetrorelix (+) group.
April 2019
Vol. 51, Iss. 2, Pages 399-799
