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In-vivo Evaluation of Anti-urolithiatic Activity of Different Extracts of Peel and Pulp of Cucumis melo L. in Mice Model of Kidney Stone Formation

In-vivo Evaluation of Anti-urolithiatic Activity of Different Extracts of Peel and Pulp of Cucumis melo L. in Mice Model of Kidney Stone Formation

Aneeqa Saleem1, Muhammad Islam1, Hamid Saeed1* and Mehwish Iqtedar2

1University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, 54000, Lahore, Pakistan
2Department of Biotechnology, Lahore College for Women University, Jail Road, Lahore, Pakistan

*      Corresponding author: hamid.pharmacy@pu.edu.pk

Fig. 1.

Primary metabolites in Cucumis melo L. and establishment of mice model of kidney stone formation. Lipids (A), proteins (B) and carbohydrates (C) in peel (brown bars) and pulp (black bars) of Cucumis melo L. serum creatinine (D), uric acid (E) and BUN (blood urea nitrogen) (mg/dL) (F) levels at day1 (grey bars) and day 10 (black bars) after intraperitoneal injections of ethylene glycol (0.75% V/V).

Fig. 2.

Anti-urolithiatic activity of extracts of peel and pulp of Cucumis melo L. Serum creatinine levels (mg/dL) (A), serum uric acid levels (mg/dL) (B) and serum BUN levels (mg/dL) (C). White bars represent normal samples, green bars represent positive control and black bars represent negative control. * indicates p-values of ≤ 0.05.

Pakistan Journal of Zoology

June

Vol. 53, Iss. 3, Pages 801-1200

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