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Identification of Ten New N-acetyldopamine Dimers from Periostracum Cicadae

Identification of Ten New N-acetyldopamine Dimers from Periostracum Cicadae

Lu Yang1,2*, Ke Zhang3 and Jin-Hui Wang1,2,4

1Key Laboratory of Forest Resources and Utilization in Xinjiang of National Forestry and Grassland Administration, Xinjiang Academy of Forestry, Urumqi 830052, China. 
2Key Laboratory of Fruit tree Species Breeding and Cultivation in Xinjiang, Urumqi 830052, China. 
3Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, College of Pharmacy, Shihezi University, Shihezi 832002, China. 
4College of Pharmacy, Harbin Medical University, Harbin 150081, China.
* Corresponding author:


Periostracum Cicadae is the cast-off shell of the cicada Cryptotympana pustulata Fabricius, it is a widely used animal based traditional folk medicine, it is found to have many effects including antipyretic, antiallergic and antioxidant activities. In this study, ten N-acetyldopamine dimers, named Cicadamide C1–C10 (compounds 1–10), were isolated from Periostracum Cicadae. One-dimensional NMR, two-dimensional NMR, mass spectrometry, CD spectroscopy, and chemical evidence were performed to further determine their structures. In the results, ten N-acetyldopamine dimers were isolated and their structures were elucidated. This study provides a basic reference for further biological effects study on Periostracum Cicadae.

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Pakistan Journal of Zoology


Pakistan J. Zool., Vol. 56, Iss. 1, pp. 01-501


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