Submit or Track your Manuscript LOG-IN

Harnessing CRISPR-Cas9 Gene Editing for the Eradication of Inherited Retinal Diseases in Purebred Dogs: A Path to Preservation and Health

Harnessing CRISPR-Cas9 Gene Editing for the Eradication of Inherited Retinal Diseases in Purebred Dogs: A Path to Preservation and Health

Ali Sabeeh Ali1, Noor Abdulaala Kadhim2, Entissar Mansour Abdul Rasool3, M. Al-Erjan4, Qais R. Lahhob5*, Mustafa Mudhafar6,7 

1Department of Science, College of Basic Education, University of Sumer, Thi-Qar, Iraq; 2Department of Science, College of Basic Education, University of Sumer, Thi-Qar, Iraq; 3Department of Dentistry, College of Dentistry, Al-Iraqia University, Baghdad, Iraq; 4Department of Medical Laboratory Technology, Mazaya University College, Thi-Qar, Iraq; 5College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq; 6Department of Medical Physics, Faculty of Applied Medical Sciences, University of Kerbala, Karbala, Iraq, 56001; 7Department of Anesthesia Techniques and Intensive Care, Al-Taff University College, Karbala, Iraq, 56001.

*Correspondence | Qais R. Lahhob, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq; Email: [email protected] 

Figure 1

Preservation of retinal structure in CRISPR-Cas9 treated dogs. 

Figure 2

Optical coherence tomography imaging reveals successful gene editing in inherited retinal disease. 

Figure 3

Improved retinal function in CRISPR-Cas9 treated group: electroretinography demonstrates enhanced photoreceptor and bipolar cell activity in inherited retinal disease. 

Pakistan Journal of Zoology

December

Pakistan J. Zool., Vol. 56, Iss. 6, pp. 2501-3000

Featuring

Click here for more

Subscribe Today

Receive free updates on new articles, opportunities and benefits


Subscribe Unsubscribe