Functional and Histological Signs of Early Detection of Liver and Kidney Stress Under the Influence of Tramadol Oral Administration in Male Rats
Functional and Histological Signs of Early Detection of Liver and Kidney Stress Under the Influence of Tramadol Oral Administration in Male Rats
Hawraa F.H. Alowaid1*, Afrah Adil Hassan1, Majdy Faisal Majeed2
Semi quantified data of biochemical alteration as biomarker to overdose stress of TML (15 and 30md/kg/day) for up 30 days, (A) serum enzymatic concentration, AST, ALT, and ALP, (B and C) The concentration of MAD and NO metabolites, (D and E) tissue enzymatic activity, SOD and CAT. Mean ± SD, n= 5 per sample, P≤0.05.
Paraffin sections of experiment groups liver, (A 1000 X) H group liver note severe Inflammation infiltration (white arrow), necrosis (circle), and apoptosis state (black arrow), as well as (B 400X) shown a hemorrhage (white arrow), severe degeneration and vaculation of cytoplasm (circle), while (C 400X) note dilated sinusoids (black arrow). L group notes (D 400X) mild Inflammation infiltration (black arrow), and necrosis (circle), while (E 400X) shown a hemorrhage (black arrow), (F 100X) note apoptosis state (black arrow) and dilated sinusoids (arrow head). (H and E staining).
