Evaluation of Anxiolytic Activity of Pulsatilla nigricans L. in Wistar Rats by using Elevated Plus Maze and Hole Board Paradigms
Evaluation of Anxiolytic Activity of Pulsatilla nigricans L. in Wistar Rats by using Elevated Plus Maze and Hole Board Paradigms
Rafia Sadaf1, Ishrat Younus2*, Sidra Maqbool2, Talha Bin Fayyaz3, Sarah Jameel Khan1, Sidra Siddique1 and Rida Fatima1
ABSTRACT
Pulsatilla nigricans Linn has traditionally been used in various disorders related to both male and female and proves a great remedy for ovaralgia, ovaritis, epididymitis, orchitis nervousness, sadness, mild restlessness and mental disorder. This investigation is designed to evaluate acute toxicity and anti-anxiety activity of ethanol extract of Pulsatilla nigricans leaves. The acute oral toxicity shows that, plant extract up to 5000 mg/kg produces no signs and symptoms related to toxicity and also no mortality was observed. Antianxiety activity of Pulsatilla nigricans was examined by using elevated plus-maze paradigm and hole-board paradigm in rats at two different doses i.e. 250 and 500 mg/kg, and significant anxiolytic effects were observed as compare to control.
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June 2020
Vol. 52, Iss. 3, Pages 825-1224
