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Evaluation of Antioxidant, Nephroprotective and Immunomodulatory Activity of Vitamins C and E -Sodium Selenite in Mice Intoxicated with Sodium Nitrate

Evaluation of Antioxidant, Nephroprotective and Immunomodulatory Activity of Vitamins C and E -Sodium Selenite in Mice Intoxicated with Sodium Nitrate

Marah Salim Hameed1, Ali Ibrahim Ali Al-Ezzy2*

1Department of Physiology Biochemistry and Pharmacology, College of Veterinary Medicine, University of Diyala, Iraq; 2Department of Pathology, College of Veterinary Medicine, University of Diyala, Iraq.

 
*Correspondence | Ali Ibrahim Ali Al-Ezzy, Department of Pathology, College of Veterinary Medicine, University of Diyala, Iraq; Email: alizziibrahim@gmail.com

Figure 1:

Levels of serum urea and creatinine (mg/dl) according to experimental groups.

Figure 2:
A: Normal control mice show renal corpuscle consists of glomerulus and a two-layered glomerular Bowman’s capsule that encloses glomerulus; the proximal convoluted tubules and distal convoluted tubules. B: Histopathological Changes of mouse kidney for sodium nitrate treated group: In the cortex, there is a sever congestion of renal blood vessels, perivascular cuffing, and infiltration of inflammatory cells in the dilated blood vessels. Extensive distension of Bowman’s space with sever congestion of glomerular capillaries and extensive cellular swelling of proximal and distal convoluted tubules with vacuolar degeneration surrounding proximal and distal convoluted tubules and tubule necrosis with dilation and vacuolar degeneration of proximal and distal convoluted tubules. C: Histopathological Changes of mouse kidney for (Vitamin E -sodium selenite received group): In the cortex, there is a congestion of renal blood vessels, perivascular cuffing, and infiltration of inflammatory cells in the dilated blood vessels. Distension of Bowman’s space. Congestion of glomerular capillaries, proximal and distal convoluted tubules showed cellular swelling. D: Histopathological Changes of mouse kidney for (Vitamin C treated group): In the cortex, there is a congestion of renal blood vessels, perivascular cuffing, and infiltration of inflammatory cells in the dilated blood vessels. Congestion of glomerular capillaries, proximal and distal convoluted tubules showed cellular swelling. E: Histopathological Changes of mouse kidney for sodium nitrate and vitamin E treated group: In the cortex, there is a sever congestion of renal blood vessels, perivascular cuffing, and infiltration of inflammatory cells in the dilated blood vessels. Extensive distension of Bowman’s space with atrophic changes and sever congestion of glomerular capillaries, extensive cellular swelling of proximal and distal convoluted tubules. F: Histopathological Changes of mouse kidney for sodium nitrate and vitamin C treated group: In the cortex, there is a sever congestion of renal blood vessels, perivascular cuffing, and infiltration of inflammatory cells in the dilated blood vessels. Distension of Bowman’s space and sever congestion of glomerular capillaries, extensive cellular swelling of proximal and distal convoluted tubules with cellular debris.
Figure 3:

Positive deep blue color indicates intracytoplasmic formazan formation by peritoneal monocytes-macrophages. Negative cells appear as pale shadow with intact cellular membrane.

Advances in Animal and Veterinary Sciences

June

Vol. 12, Iss. 6, pp. 994-1205

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