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Effects of Propofol and Vitexin on Apoptosis in Rat Liver Ischemia Reperfusion Injury

Effects of Propofol and Vitexin on Apoptosis in Rat Liver Ischemia Reperfusion Injury

Jie He* and Ren Yang

Department of Anesthesiology, Zhuji People’s Hospital of Zhejiang Province, No. 9, Jianmin road, Taozhu street, Zhuji, Zhejiang province, 311800, China

 
* Corresponding author: v5rkhy@163.com

ABSTRACT

Fifty rats were randomly divided into sham group, model group, propofol group, vitexin group and propofol + vitexin group,with 10 rats each group. Rat model of whole liver ischemia-reperfusion injury was established according to Pringle’s method. Results showed that compared with propofol group and vitexin group, levels of serum ALT, AST and LDH in propofol + vitexin group were reduced (P < 0.05), apoptosis index was reduced (P < 0.05), Bcl-2 protein expression was increased (P < 0.05), Bax protein and caspase-3 protein expression was decreased (P < 0.05). In conclusion, propofol and vitexin could up-regulate expression of Bcl-2 protein, down-regulate expression of Bax and caspase-3 protein, inhibit cell apoptosis, reduce liver damage indexes, and have certain protective effects on liver ischemia-reperfusion injury. The effect of propofol combined with vitexin is better than that of propofol and vitexin alone.

 

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Pakistan Journal of Zoology

August

Vol. 54, Iss. 4, Pages 1501-2001

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