Effects of Propofol and Vitexin on Apoptosis in Rat Liver Ischemia Reperfusion Injury
Effects of Propofol and Vitexin on Apoptosis in Rat Liver Ischemia Reperfusion Injury
Jie He* and Ren Yang
ABSTRACT
Fifty rats were randomly divided into sham group, model group, propofol group, vitexin group and propofol + vitexin group,with 10 rats each group. Rat model of whole liver ischemia-reperfusion injury was established according to Pringle’s method. Results showed that compared with propofol group and vitexin group, levels of serum ALT, AST and LDH in propofol + vitexin group were reduced (P < 0.05), apoptosis index was reduced (P < 0.05), Bcl-2 protein expression was increased (P < 0.05), Bax protein and caspase-3 protein expression was decreased (P < 0.05). In conclusion, propofol and vitexin could up-regulate expression of Bcl-2 protein, down-regulate expression of Bax and caspase-3 protein, inhibit cell apoptosis, reduce liver damage indexes, and have certain protective effects on liver ischemia-reperfusion injury. The effect of propofol combined with vitexin is better than that of propofol and vitexin alone.
To share on other social networks, click on any share button. What are these?
