Effect of Resveratrol on Fatty Acid Compositons and Lipophilic Vitamins of Fructose Induced Nonalcoholic Fatty Liver
Effect of Resveratrol on Fatty Acid Compositons and Lipophilic Vitamins of Fructose Induced Nonalcoholic Fatty Liver
Mehmet Guvenc1,*, Ayşe Nilay Guvenc3, Ökkeş Yılmaz2 and Mehmet Tuzcu2
ABSTRACT
İn this study, the effect of resveratrol on the liver of rats induced by fructose was investigated. Adult male Winstarrats were randomly divided into four groups; control, resveratrol, fructose, and resveratrol plus fructose. Resveratrol was administered 30 mg/kg intraperitoneally. Fructose (10% w/v) was administered with drinking water for 56 days every alternate day. Fructose administration increased the hepatic omega-6/omega-3 and 16:1 n7 / 16:0 ratios (p<0.001, p<0.001), but decreased the retinol and alfa tocoferol levels (p<0.01) compared with control group. Resveratrol administration to fructose treated rats decreased the retinol and cholesterol levels (p<0.01, p<0.05), and increased alfa tocoferol and vitamin d3 levels (p<0.01) in the liver. Our results suggest that resveratrol act as a bioregulator for some biochemical parameters in fructose induced non-alcoholic fatty liver.
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December 2017
Vol. 49, Iss. 6, Pages 1937-2341
