Present study was intended to evaluate the effect of vitamin E and selenium supplementation on passive transfer of antibodies in colostrum and calves against FMD and HS vaccine. Thirty-five pregnant cattle were selected and seven groups were made consisting five cattle. Group A was controls: Animals in Group B and C were at 45 days prepartum with and without VES: animals in D and E were at day 60 prepartum with and without VES: animals in F and G were at 75 days prepartum stage with and without VES: respectively. At day 0 of experimental trial VES was given to animals in group C, E and G. All groups were given oil based HS vaccine at day 15 and alum based FMD trivalent vaccine at day 30 of experimental trial except Group A. Blood samples from adult cattle were collected at day 0, 15 and 30 after parturition and in cattle calves at age of 0, 14, 28 and 42. Colostrum sample was collected at 0, 12 and 24 h after parturition. Antibody titer was determined by Complement fixation test. Results showed that highest antibody titer was developed in cattle, colostrum and their calves in group G in which treatment was started 75 days prepartum and VESS was given. It was concluded that vitamin E and selenium supplementation improves both active and passive immune system if given before 75 days of parturition.
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