Effect of Lactobacillus rhamnosus (NR_113332.1) on Creatine Kinase and Lactate Dehydrogenase Levels in Orthrotopically Transplanted EDL Muscle of Mice
Effect of Lactobacillus rhamnosus (NR_113332.1) on Creatine Kinase and Lactate Dehydrogenase Levels in Orthrotopically Transplanted EDL Muscle of Mice
Shamsa Jabeen and Javed Iqbal Qazi*
ABSTRACT
Creatine kinase (CK) and lactate dehydrogenase (LDH) are myosin heavy chain associated molecules which do not have the capacity to cross muscle cell membrane under normal conditions. Their increase in serum concentration have been used as indicators for muscle damage. The aim of the current study was to determine the effect of Lactobacillus rhamnosus administration on CK and LDH levels in the serum of mice following extensor digitorium longus (EDL) muscle grafting. Blood from the intact control as well as experimental and EDL muscle grafted mice was secured on day 3, 5, 7 and 14 post-transplantations. CK activity of control and EDL muscle grafted mice with probiotics showed 157% and 130% increase, respectively on day 5, whereas on 14th days post-transplantation CK values showed 45.6% and 4%, respectively increase compared with the values of intact control. The LDH activity increase 52.27% and 19.46%, respectively on day 7 when compared with intact control. On 14th days post-transplantation corresponding values for control and probiotics were 23.0% and 1.7 %, respectively increase when compared with the value of intact control. Current study revealed that probiotic administration in orthotropic-transplanted EDL muscle reduce CK and LDH activities in mice, which is positive indication for increase in muscle regeneration.
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