Dependence of Antioxidant and Biochemical Status on Selenium Content in the Blood of Animals
Dependence of Antioxidant and Biochemical Status on Selenium Content in the Blood of Animals
Vladimir Safonov
ABSTRACT
Inadequate nutrition of the body with selenium can adversely affect the oxidant-antioxidant status of the animal since this microelement belongs to the most important antioxidant defense enzyme glutathione peroxidase. This article examines the intensity of lipid peroxidation processes and the functioning of the antioxidant defense system in pregnant and calved cows in the area with selenium favorable agrobiocenoses (Voronezh region, Russian Federation) and selenium-deficient biogeochemical province (Kirov region, Russian Federation). The LPO-AOS parameters were evaluated in 89 Black-Motley cows at the age, corresponding to 2 to 3 lactations, with mean or great live market quality and a weight of 500 to 650 kg. The content of microelements, malonic dialdehyde, enzymatic and non-enzymatic components of the antioxidant defense system in the blood was investigated. Biochemical analysis of the blood was also performed to estimate the functional state of the cow’s organism. In animals from the selenium-deficient region, the microelement content did not exceed 44.2–81.9% of the level in animals from the satisfactory region throughout all studied groups. Besides, an increased accumulation of lipid peroxidation products was observed. In particular, malonic dialdehyde increased by 17.9–96.6%. Also, the malfunction of the glutathione system was noted, manifested in the reduced activity of glutathione peroxidase and glutathione reductase. The consumption of Vitamin E as a non-enzymatic element within the antioxidant defense system increased significantly by up to 2.27 times. Study results of the blood biochemical composition show that selenium deficiency may facilitate the development of pathologies in the liver and excretory system . Therefore, food additives as an additional source of micronutrients may be recommended to maintain the antioxidant defense system capability in animals with low selenium levels in agrobiocenoses.
Keywords | Antioxidant protection, Biochemical composition, Cows, Pathology, Peroxidation, Selenium
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