Theobjective of the study was to observe the effect of mifepristone combined with Guizhifuling capsule in the treatment of uterine fibroids. Patients (160) diagnosed and treated for uterine fibroids in our hospital were enrolled as research objects. The patients were randomly divided into an experiential group and a control group, each containing 80 patients. The experiential group was treated with mifepristone and Guizhifuling capsule, and then subjected to high quality nursing. In contrast, the control group was treated with only mifepristone therapy and applied with routine nursing measures. The therapeutic and nursing effects of the two groups were compared. After the implementation of different treatment and nursing mode, the overall treatment effective rate of the research group patients was 97.50%, which was significantly higher than 75.00% of control group, p<0.05. Through comparing the changes of fibroid volume before and after treatment between the two groups, the results showed that the improvement effect of the research group was significantly better than that of the control group after treatment, p<0.05. The incidence of adverse reactions of the research group was significantly lower than that of control group, while the and overall nursing satisfaction of the research group was significantly higher than that of the control group, p<0.05. It is concluded that combination therapy of mifepristone and Guizhifuling capsule can significantly improve the treatment effect in patients with uterine fibroids.