Computational Pharmacophore Modelling of 5-HT2a and D2 Receptor Inhibitors of Schizophrenia
Computational Pharmacophore Modelling of 5-HT2a and D2 Receptor Inhibitors of Schizophrenia
Rida Zainab1, Sana Elahi1, Afshan Kaleem2,*, Daniel C. Hoessli3, Mehwish Iqtedar2, Roheena Abdullah2, Faiza Saleem2, Shanza Khan1, Anusha Ijaz1, Shagufta Naz2 and Abdul R. Shakoori4,5,*
Fig. 1.
Pharmacophore model of Blonanserin (A), Clozapine (B) and Iloperidone (C).
Fig. 2.
Pharmacophore model of Lurasidone (A), Melperone (B) and Mosapramine (C).
Fig. 3.
Pharmacophore model of Olanzapine (A), Paliperidone (B) and Perospirone (C).
Fig. 4.
Pharmacophore model of Quetiapine (A), Risperidone (B) and Tiospirone (C).
Fig. 5.
Pharmacophore model of Ziprasidone (A), Zotepine (B) and Fluperlapine (C).
Fig. 6.
Combined Pharmacophore model of all the 15 ligands.
Fig. 7.
Minimum and maximum distance ranges among all the features.
December 2018
Vol. 50, Iss. 6, Pages 1999-2398
