Abstract | To research out an efficient chemical remedy of broad-leaved weeds in winter wheat at Pothwar Region of Pakistan, a study was performed during 2016-17 at University Research Farm Chakwal Road Rawalpindi. Four herbicides were used as once and twice application, i.e., Buctril Super (Bromoxinil 30% with MCPA 30% w/v), Ally Max (Metsulfuron Methyl 14.3% w/w with Tribenuron Methyl 14.3% w/w), Starane M (Fluroxypyre 10% with MCPA 40% w/w) and Clean wave (Aminopyralid 1% with Fluroxypyre14% w/w) at recommended doses. A weedy check and a weed free plot were also kept for comparison. Results showed that in comparison to control plot (weedy check), there was 73.41% increase in the grain yield of wheat where double spray of Ally Max was done and it was followed by 58.28%, 54.78%, 51.28% and 36.59% where double spray of clean wave, Buctril Super, Starane Mand single hand weeding were applied respectively. Similarly, there was 70.1% decrease in the seed bank of weeds where Starane M was sprayed twice as compared with control plot which was followed by 69.17%, 69%, 61.39% and 45.18% decrease where Ally Max twice, Buctril Super twice, clean wave twice and once hand weeding were applied respectively. So, resultantly, it is concluded that twice application of all tested herbicides gave best results for controlling flora and weeds seed bank of prevailing weeds which significantly increased the wheat yield. So, twice application of Starane M, Ally Max, Buctril Super and Clean Wave herbicides is recommended to improve the productivity of wheat along with efficient control of weed seed bank and weed flora in wheat under rain-fed conditions of Pothwar Region of Pakistan.