Biological Relevance of C-terminal Elongation of the NS1 Protein of Influenza A Viruses
Biological Relevance of C-terminal Elongation of the NS1 Protein of Influenza A Viruses
Weili Kong1, Guangpeng Ma2 and Jinhua Liu1*
ABSTRACT
The non-structural 1 (NS1) protein plays a crucial role in moderating the virulence of influenza virus by multiple mechanisms. Due to C-terminal ‘tail’ (CTT) truncation of NS1, there are length variation types of NS1 in different subtype influenza viruses. CTT functions in several ways to defeat the cellular innate immune responses. Here, we discuss those different effects of CTT truncation or elongation of NS1 protein in different genetic backgrounds of influenza experimentations. Conclusively, it can be stated that CTT confers a positive role during the infection of influenza A viruses. However, this regulation is contributed by multiple factors and has variable impact on the pathobiology of influenza A viruses.
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