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Bioinformatic Analysis of the Transcriptome Profile of Adult Female Angiostrongylus cantonensis

Bioinformatic Analysis of the Transcriptome Profile of Adult Female Angiostrongylus cantonensis

Yue Guo1,2*, Hui Zhang1, Chun Sheng Wang1 and Hong Chang Zhou1

1School of Medicine, Huzhou University, 759 Erhuan Rd, Huzhou, Zhejiang, Peoples R China 
2Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou University, Huzhou, Zhejiang, Peoples R China
Yue Guo and Hui Zhang contributed equally to this study.
* Corresponding author:


To perform transcriptional profiling of adult female Angiostrongylus cantonensis, three groups of adult female A. cantonensis were isolated and their mRNA was separated and sequenced through the next-generation sequencing (NGS) technology. Sequencing data were assembled into unigenes and transcripts. Finally, all unigenes and transcripts were annotated by querying the NR, Gene Ontology (GO), COG and KOG databases.A total of 71047 unigenes and 106652 transcripts were assembled. A. cantonensis was successfully annotated by the NR and GO databases, resulting in 8107 unigenes and 16105 transcripts. Meanwhile, 10422 unigenes and 20974 transcripts were annotated by the COG/KOG databases. ORF querying annotated 10531 unigenes and 28186 transcripts. It could be observed that the unigenes and transcripts associated with metabolism and parasitism of adult female A. cantonensis were highly expressed.In this study, the transcriptome of adult female Angiostrongylus cantonensis was analyzed and successfully annotated. Metabolism and parasitism related genes were highly expressed at adult female A. cantonensis.

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Pakistan Journal of Zoology


Vol. 55, Iss. 3, Pages 1003-1500


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