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Association of Chemokine Genes CXCL9 and CXCL10 Polymorphisms with Tuberculosis in Pakistani Population

Association of Chemokine Genes CXCL9 and CXCL10 Polymorphisms with Tuberculosis in Pakistani Population

Saleha Tabassum1, Muneeza Zafar1,2, Munazza Raza Mirza1*, Muhammad Iqbal Choudhary1,3, Ikram ul Haq4, Imran Riaz Malik2, Ambreen Ansari1 and Mehtab Alam5

1Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, 75270, Pakistan.
2University of Sargodha, Sargodha, Pakistan.
3H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, 75270, Pakistan. 
4Institute of Biotechnology and Genetic Engineering, University of Sindh, Jamshoro, Pakistan.
5Department of Biochemistry, Dow University of Medical and Health Sciences, Ojha Campus. Karachi, Pakistan.
 
Saleha Tabassum and Muneeza Zafar equally contributed and are co-first authors.
 
* Corresponding author: munzihyder@yahoo.com

Fig. 1.

(A) Tri-ARMS PCR assay based genotyping of CXCL10 rs5606198 (G/A) polymorphism on 2.5% agarose gel. Lane L shows 1000 bp molecular marker, lane 1 and 2 shows positive control with GA genotype. Lanes 3, 4 and 5,6 represents GA genotype with band size of 545 and 295bp. (B) T-ARMS PCR assay based genotyping of CXCL9 rs2276886 (G/A) polymorphism on 2.5% agarose gel. Lane L shows 1000 bp molecular marker, lane 1 shows positive control. Lanes 3, 4 and 5 shows GG genotype of 232 bp along with control band of 595 bp. Lanes 1, 7 represent GA genotype with both bands of 4081 bp and 232 bp along with control of 595 bp. Lane 2 represents AA genotype with both bands of 408bp and 595bp.

Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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