Assessing Wound Healing Diameter and Morphological Change in Rabbits: The Impact of Lidocaine, Remifentanil (With and Without Adjuvants), and Tramadol in Burn Wound Healing
Assessing Wound Healing Diameter and Morphological Change in Rabbits: The Impact of Lidocaine, Remifentanil (With and Without Adjuvants), and Tramadol in Burn Wound Healing
Nabaa Fadhil Abbas*, Raffal A. Omar
ABSTRACT
This study aimed to evaluate the effects of tramadol and remifentanil on burn wound healing in rabbits. The research involved 30 rabbits divided into five groups: G1 (Lidocaine), G2 (Tramadol), G3 (Remifentanil), and two groups that received combinations of remifentanil with epinephrine. Additionally, one group received remifentanil in a gel formulation. After local administration of these substances by infiltration (s/c) and compared with the control group. the severity of the burn injury and subsequent healing were assessed from first-degree burns. The study results revealed that tramadol and remifentanil with epinephrine significantly slowed down the wound-healing process in rabbit burn models compared to the other groups studied. This study investigated the effects of different medications on wound healing in rabbits. The results at various time points, including 7 days, 14 days, and 21 days, were analyzed. At 7 days post-treatment, Tramadol showed a reduction in wound diameter compared to the control group, suggesting potential wound healing effects. The combination of Remifentanil with epinephrine further reduced the wound diameter, indicating enhanced wound healing effects. The addition of gel to Remifentanil did not significantly impact wound healing compared to the Remifentanil and epinephrine combination. At 14 days, Lidocaine resulted in a more significant reduction in wound size compared to other groups. Tramadol showed a relatively larger wound size, suggesting less effectiveness in promoting wound healing. Remifentanil alone did not significantly reduce wound size. Remifentanil with gel and Remifentanil with epinephrine had a more pronounced effect on wound healing. At 21 days, Tramadol contributed to the complete healing of burn wounds. Lidocaine led to a relatively smaller wound size, while Remifentanil alone did not result in complete healing. The combination of Remifentanil with gel did not lead to full wound closure. Remifentanil with epinephrine resulted in the complete healing of burn wounds. The examination revealed that the outermost layer of the skin, known as the epidermis, appeared normal in thickness and structure, indicating the restoration of turnover and regeneration of epidermal cells to normal levels. The study concluded that tramadol and remifentanil with epinephrine impede burn wound healing in rabbits, highlighting the need for caution in their use.
Keywords | Lidocaine, Remifentanil, Tramadol, Wound healing, Rabbits, Adjuvants
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May 2024
Vol. 12, Iss. 5, pp. 802-993
