Aptamers as Viral Replication Antagonists
Aptamers as Viral Replication Antagonists
Nicola J. Stonehouse
ABSTRACT
Aptamers are nucleic acids, selected in vitro to specifically bind target molecules. They can therefore be useful as molecular tools and also as novel therapeutic agents. This commentary describes RNA aptamers selected to bind to the RNA-dependent-RNA polymerase of foot-and-mouth disease virus. The aptamers are able to inhibit the function of the enzyme both in vitro and in the context of a sub-genomic replicon and highlight the future potential of this technology in many aspects of virus research as well as in diagnostics and therapeutics.
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October 2014
Vol. 1, Iss. 1, Pages 1-16
