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Antiviral Potential of Ivermectin against Peste des Petits Ruminants Virus (PPRV)

Antiviral Potential of Ivermectin against Peste des Petits Ruminants Virus (PPRV)

Saba Afzal1, Sohail Raza1,*, Masood Rabbani1, Sehrish Firyal2, Imran Altaf1 and Zahra Naeem1

1Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore
2Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore

*     Corresponding author: sohail.raza@uvas.edu.pk

Fig. 1.

Antiviral activity of Ivermectin against PPRV. A, confluent Vero cells were exposed with different concentrations of ivermectin and cell cytotoxcic concentrations were determined 48 hrs post drug exposure using MTT assay. B, antiviral activity of ivermectin was determined using TCID50 after drug exposure during the course of infection. C, cellular morphology at 400x magnification under microscope in control cells and drug treated cells after infection. D, effect of ivermectin on viral attachment and penetration. E, effect of ivermectin on post entry stages of viral replication (0µM, virus control without drug; 0µM+DMSO, DMSO control; 2.5µM, ivermectin 2.5µM).

Pakistan Journal of Zoology

June

Vol. 53, Iss. 3, Pages 801-1200

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