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The Effect of Kanglaite Injection on Apoptosis of Colon Cancer SW480 Cells and Expression of Apoptosis-Related Factors

The Effect of Kanglaite Injection on Apoptosis of Colon Cancer SW480 Cells and Expression of Apoptosis-Related Factors

Yujun Zhao and Jianping Fan*

Gastrointestinal Surgery, Quzhou People’s Hospital, Quzhou324000, Zhejiang, China

*     Corresponding author: qyjs8zt@163.com

ABSTRACT

The aim of our present study was to assess the effects of Kanglaite injection on apoptosis and expression of apoptosis-related factors Bcl-2 and Bax protein and the activities of Caspase-3 and Caspase-8 in colon cancer SW480 cells were studied. Compared with the control group without medication, the proliferation inhibition rate of cells processed with Kanglaite injection (10, 20 and 40 μL/mL) significantly increased (p <0.05), the apoptosis rate increased (p <0.05), the expression of Bcl-2 protein decreased (p <0.05), the expression of Bax protein significantly increased (p <0.05), and the activity of Caspase-3 and Caspase-8 increased (p <0.05) in a dose-dependent manner. Hence, this can be concluded that Kanglaite injection can effectively inhibit the proliferation and induce apoptosis of SW480 cells, which may be correlated with the inhibition of Bcl-2 expression, the promotion of Bax expression and the enhancement of caspase activity.
 

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Pakistan Journal of Zoology

February

Vol. 53, Iss. 1, Pages 1-400

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