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RNAi-Based Treatment for Rabies: Current Achievements and Insights Towards a Cure

RNAi-Based Treatment for Rabies: Current Achievements and Insights Towards a Cure

Paulo Eduardo Brandao

Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine, University of São Paulo, Brazil. Av.Prof. Dr. Orlando M. Paiva, 87, Cidade Universitária, CEP 05508-270, São Paulo, SP, Brazil.

ABSTRACT

Due to the lack of success of antivirals in inhibiting rabies virus intracellular cycle both in vitro and in vivo, and the high failure rate of this treatment in human patients, the use of RNA interference (RNAi) for Post-transcriptional Gene Silencing (PTGS) has witnessed an increasing interest from those concerned with a cure for rabies, inspired on the success obtained for other viral diseases. This review is intended to present the current situation of RNAi against rabies, as well as insights into the future on the field.

 

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Hosts and Viruses

June

Vol.6, Iss.3, Pages 42-84

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