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Protective Effect of Caffeic Acid on Streptozotocin Induced Gestational Diabetes Mellitus in Rats: Possible Mechanism

Protective Effect of Caffeic Acid on Streptozotocin Induced Gestational Diabetes Mellitus in Rats: Possible Mechanism

Ying Liu1, Shankun Liu1, Hui Wang2 and Weihua Su2,*

1Department of Gynecology, Taian City Central Hospital, No. 29, Longtan Road, Taian, Shandong Province, 271000, China
2Departmrnt of Obstetrics, Taian City Central Hospital, No. 29, Longtan Road, Taian, Shandong Province, 271000, China

*      Corresponding author: sdtasuweihua@sina.com

Fig. 1.

The effect of caffeic acid on the blood glucose level (A), body weight (B) and serum AGEs (C) of streptozotocin (STZ) induced gestational diabetes mellitus (GDM) induced rats at regular time intervals. Dunnett’s multiple test was performed for the statistical analysis. Treated group rats compared with the STZ induced GDM group rats. *p<0.05 consider as the significant, **p<0.01 consider as the more significant and ***p<0.001 consider as the most significant.

Fig. 2.

The effect of caffeic acid on the biochemical parameter of streptozotocin (STZ) induced gestational diabetes mellitus (GDM) induced rats at end of the experimental study. A, the HbA1c, serum C-peptide, free fatty acid, FINSand; B, hepatic glycogen. Dunnett’s multiple test was performed for the statistical analysis. Treated group rats compared with the STZ induced GDM group rats. *p<0.05 consider as the significant, **p<0.01 consider as the more significant and ***p<0.001 consider as the most significant.

Fig. 3.

The effect of caffeic acid on the fetus weight, placental weight and placental index of streptozotocin (STZ) induced gestational diabetes mellitus (GDM) induced rats at end of the experimental study. A, fetuses weight; B, placental weight; C, placental index. Dunnett’s multiple test was performed for the statistical analysis. Treated group rats compared with the STZ induced GDM group rats. *p<0.05 consider as the significant, **p<0.01 consider as the more significant and ***p<0.001 consider as the most significant.

Fig. 4.

The effect of caffeic acid on the lipid parameters of streptozotocin (STZ) induced gestational diabetes mellitus (GDM) induced rats at end of the experimental study. A, triglycerides; B, total cholesterol; C, HDL; D, LDL; E, VLDL. Dunnett’s multiple test was performed for the statistical analysis. Treated group rats compared with the STZ induced GDM group rats. *p<0.05 consider as the significant, **p<0.01 consider as the more significant and ***p<0.001 consider as the most significant.

Fig. 5.

The effect of caffeic acid on the antioxidant parameter in liver (A) and pancreas (B) of streptozotocin (STZ) induced gestational diabetes mellitus (GDM) induced rats at end of the experimental study. a, SOD, GPx, CAT, GSH; b, MDA. Dunnett’s multiple test was performed for the statistical analysis. Treated group rats compared with the STZ induced GDM group rats. *p<0.05 consider as the significant, **p<0.01 consider as the more significant and ***p<0.001 consider as the most significant.

Pakistan Journal of Zoology

April

Vol. 53, Iss. 2, Pages 401-800

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