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Correlation between Biochemical and Anti-Oxidative status in Rheumatoid Arthritis Patients Update from Lahore, Pakistan

Correlation between Biochemical and Anti-Oxidative status in Rheumatoid Arthritis Patients Update from Lahore, Pakistan

Hafiz Muhammad Arsalan1, Maria Altaf1, Zeemal Seemab Amin1, Muhammad Khalil Ahmad Khan2, Anum Shahzadi1, Hina Mudasser1, Iqra Maqsood1, Nazia Gulshan1, Saira Naseem3

1School of Biochemistry / MLT, Faculty of Allied Health Sciences, Minhaj University Lahore, Pakistan
2Department of Zoology, University of Okara, Pakistan
3Shareef Medical Complex, Lahore, Pakistan

Corresponding Author: Hafiz Muhammad Arsalan

 arsalan.mlt@mul.edu.pk

 

ABSTRACT

Bones determinedly altered through integration body matrix osteoblast, resorption bone via osteoclasts. Rheumatoid arthritis allied with considerable levels pain, tiredness, disability, reduced distinction life. Precise pathogenesis job rheumatoid factor not known, through formation immune complexes engross establishment harmonize. To determine the correlation between Anti-Oxidants and Biochemical status in Rheumatoid Arthritis patients. 60 clinically diagnosed Rheumatoid Arthritis (RA) patients and 50 healthy persons were included in this study. 5 ml Blood was drawn and serum was separated. Anti-Oxidant Biomarkers, Serum micronutrients, serum Electrolyte balance was measured through spectrophotometric procedure. Serum MDA level jump high in patients (14.19) as compared to normal subjects (3.26). Serum Glutathione declined in disease persons (0.56) from healthy subjects (6.39). Serum Micronutrients level was also declined in RA patients as compared to healthy persons and substantial statistically (P=0.000). Serum Nitric Oxide jump high in patients (32.11) than normal persons (15.2). Abnormal concentration of reactive oxygen species can disturb the body’s defense mechanism which cause potential oxidative injury to tissues and lead to cartilage degradation in RA patients.
 

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Punjab University Journal of Zoology

December

Vol. 34, Iss. 2, pp. 105-238

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