Rafa Almeer1,*, A. Alqarni1,2, S. Alqattan3, S. Abdi4,*, S. Alarifi1, Z.Hassan5 and A. Semlali6
...ree tissue inhibitors of metalloproteinase (TIMPs) and two matrix metalloproteinase (MMPs) were measured by real-time PCR. All subgroups exhibited altered morphology with accelerated detachment compared to untreated cells. The MTT assay after 48 h revealed that treatment with H1 and H2, reduced cell viability by 48% and 91% respectively, compared to that of untreated cells. These results suggest that anticancer effect of Sid...
Kun Wang1,2, Yinglin Cui2, Xu Zhao2 and Changjiang Hu1*
...e 3b (DNMT3b) and Matrix metalloproteinase-9 (MMP-9) was evaluated by western blot. And microRNA-29b was identified using quantitative real-time PCR. 3). Compared with the Model group, the group treated with XN had a significantly reduced number of dead neurons in hippocampus and cortical regions of ICH rats. Furthermore, this treatment significantly increased protein expression of claudin-5, ZO-1 and VE-cadherin while protein expression of DNMT3b and MMP-9 we...
Xiaojing Liu and Zhongxin Li*
...factor (VEGF) and matrix metalloproteinase (MMP-) 9 protein expression in kidney tissues, in order to reveal the mechanism of TSG. After 12 weeks of administration, compared with those in the DN modeling group, 24 h urine protein, serum creatinine (Scr), blood urea nitrogen (BUN), blood uric acid (UA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) significantly reduced in rats treated with TSG (20 mg/kg) (P<0.05), blood total protein (...
Zhaojun Wang1, Yang Zhou2 and Xinghua Song3*
...cantly lower, and matrix metalloproteinases content was also significantly reduced (P<0.05). IL-1β, IL-6 and TNF-α in the observation group were respectively 8.07±3.13 ng/mL, 9.31±6.83 ng/mL and 7.72±1.86 pg/mL, with MMP-3 and MMP-9 contents at 29.42±6.74 and 20.23±5.24, showing significantly superior improvement compared with the control group and indicating statistically significant difference (P<0.05). The...
Asmaa A. Darwish*, Mona A. Mahmoud, Adel M. El-Kattan
...idemia, increased matrix metalloproteinases activity, T/HDL/LDL-hypocholesterolemia, and decreased minerals, electrolytes, and trace elements concentrations and these changes were more prominent in goat than in sheep. While, the diseased ewes suffered from higher degrees of leukocytosis, total hyperproteinemia, hypoglycemia, increased kidney function tests, and oxidative stress than the diseased does. Total antioxidant capacity (TAC) and Zn had the highest lik...
Azza M. El-Kattawy1, Tarek Abou Zed1, Randa Megahed1 and Mohammed El-Magd2*
...the expression of matrix metalloproteinase-3 (MMP3), transforming growth factor beta (TGFβ), and oxidized-LDL receptor (OLR1), 4) upregulated the expression of the anti-inflammatory gene IL10, 5) reduced the levels of the oxidative markers [lipid peroxide marker malondialdehyde (MDA) and nitric oxide (NO)], 6) increased the levels of antioxidant markers [reduced glutathione (GSH) and superoxide dismutase (SOD)]. These findings conclude that administration...
Adsadawut Sanannam1, Worawatt Hanthongkul2, Yu-Jing Liao3, Kunlayaphat Wuthijaree4, Pattaraporn Tatsapong4, Amornrat Wanangkarn4,5, Anurak Khieokhajonkhet4,5, Niran Aeksiri4,5, Sureeporn Saengwong6, Wilasinee Inyawilert4,5*
...age. Furthermore, matrix metalloproteinases (MMPs) are involved in altering the extracellular matrix (ECM) throughout pregnancy and parturition. The aim of this study was to examine changes in the characteristics of vaginal cells and alterations in the expression of matrix metalloproteinases (MMPs) using gelatin zymography in pregnant pigs. Eight sexually mature individuals were identified as being in early pregnancy using t...
Wei Li1, Hui Xu2, Si Li2 and Jing Liu2*
...1,25-(OH)2D3) and matrix metalloproteinase-9 (MMP-9) levels in the diagnosis of Kawasaki disease (KD) and prediction of coronary artery lesion (CAL) value at risk. A total of 120 children with KD were selected as the KD group, and they were divided into acute stage group (n=64) and recovery stage group (n= 56), and another 60 healthy children were selected as the healthy control group. In addition, the KD group was divided into CAL group (n=48) and non-CAL gro...
Yashu Lv*, Yueyue Gao, Jinyi Wang, Yunchun Liu and Guiqing Jiao
...ve value of serum matrix metalloproteinase-8 (MMP-8) combined with human chorionic gonadotropin (hCG) for preterm amniotic cavity infection. The study included ninety patients with preterm labor admitted from June 2021 to October 2022 in the First Affiliated Hospital of Hebei North University, including the premature rupture of membranes group and the intact fetal membranes group. The same number of pregnant women with the same gestational age as in the experi...
Mao MeiYa, Sheng Yuehua, Ding Huiqing*, Zheng Xiaojiao and Du Yongming
...ly related to the matrix metalloproteinases signaling pathway, cell surface receptor receptor interactions, and immune response signaling pathway. Our data suggest that JUN, STAT3, ETV4, ETS1, RELA and NFKB1 are key transcription factors for MMPs, and the SRC family of tyrosine kinases (LCK, LYN, and FYN), threonine kinase (ATR and ATM), CSNK2A1,CDK2 and EGFR are MMPs targets.The various miRNA targets of differentially expressed MMPs. We found significant corr...
