Abdullah Abdo Albegali1, Tayyaba Aftab1, Atiq-ur-Rehman1*, Amir Rashid1 and Mayada Mohammad1,2
...dard group and received simvastatin (10 mg/kg), while group D received a methanol extract of the plant (800 mg/kg). Lipid profile was analyzed using different kits of Roche Cobas C111 chemistry analyzer. Histopathological investigation of liver and heart was also done. The plant significantly (P < 0.05) and non-significantly (P > 0.05) decreased the levels of total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein, very low de...
Ulvi Fitri Handayani1, Wizna2, Irfan Suliansyah3, Yose Rizal2, Maria Endo Mahata2*
...tion B = 0% PTW + 0.03% simvastatin, Ration C = 6% PTW, Ration D = 12% PTW, and Ration E = 18% PTW. The administration of PTW in laying hens affected cholesterol total, LDL, and triglycerides very significant (P <0.01). The highest cholesterol is in administration 0% PTW (119.20 Mg/dL), and the lowest is in administration 0.03% Simvastatin (101,55 Mg/dL). The triglyceride content of 0% PTW (693.08 Mg/dL) and 6...
Azza M. El-Kattawy1, Tarek Abou Zed1, Randa Megahed1 and Mohammed El-Magd2*
...ypocholesterolemic drug simvastatin (Sim) has been confirmed, however, its actual mechanism of action has not been investigated yet. Therefore, this study aimed to unveil the biochemical and molecular changes that accompany the application of Sim as anti-arthritic in a mouse model of pristane-induced arthritis. Female Swiss albino mice (20-30g) were randomly divided into 5 groups (n= 10/group): control, Sim control, pristane-induced arthritis, Sim co-treated, ...
