Chenchen Liu1,2, Tong Wang1, Muhammad Khan3*, Xiaolin Cui2 and Yongming Li1,2*
Bing Yan1, Meng Meng Zhang2, Xi Chen2, Yongming Li2*, Muhammad Khan3* and Tonghui Ma1*
...is study, we showed that alantolactone (ALT) hold the capacity to suppress stem-cell-like phenotype (SCLP) of glioblastoma cells. ALT inhibited the growth, reduced mammosphere formation and down-regulated the expression of CSCs markers such as CD133, OCT4, SOX2, and NANOG in U87 and U251 glioblastoma cells in a dose-dependent manner. Further mechanistic study showed that ALT inhibits glioma SCLP and tumor growth through repression of EGFR/MOB1/LATS1/YAP signal...
