Y-STR Markers: Development, Applications and Future Prospects: An Updated Review
Y-STR Markers: Development, Applications and Future Prospects: An Updated Review
Muhammad Salman Ikram1, Tahir Mehmood1,2*, Sehrish Firyal3, Huma Sattar4, Shagufta Saeed3, Fareeha Nadeem3 and Muhammad Imran Mahmood Khan5
ABSTRACT
In forensic science, Human Y-chromosome markers are extensively used for DNA analysis of such cases with limited information of autosomal DNA profiling, difficult to obtain data or identification has to be made from Y-chromosome markers. This review describes the uniqueness of structure and relative position of Y-STRs loci, history of Y- chromosome, role of genetic markers like Y- Short tandem repeat (Y-STR) and Y- Single nucleotide polymorphism (Y-SNP), and reveal the importance of next generation sequence (NGS) as an advanced technology in forensic genetics. This manuscript also demonstrates the unique features of Y-STR markers and their different application in forensic like significance of population genetics and genealogical pattern of Y-chromosome STRs diversity in different regions of world which helps to understand the pattern of variation in DNA within and between species, importance of Y-STR in relation of its haplotype diversity and frequencies among different population, role of paternal lineages identification which helps to determine the mutation rate of Y-STR and its relationship with paternal lineages determination. When familial searching is coupled with genealogy inquiry, the review article will help us comprehend the combined use of Y-chromosome information and family information and understand the cases on the basis of specific forensic instances.
To share on other social networks, click on any share button. What are these?
