Variations in Hepatorenal profile in Hypothyroid subjects of Lahore, Pakistan
Variations in Hepatorenal profile in Hypothyroid subjects of Lahore, Pakistan
ZAHRA NASEEM1, MUHAMMAD AMIR IQBAL1, SHAAF AHMAD2 & NABILA ROOHI1*
ABSTRACT
Effects of hypothyroidism on liver and renal parameters and effectiveness of thyroid treatment (thyroxine) on these factors in hypothyroid subjects were assessed in the present investigation. A total of 140 subjects (30 subclinical and 50 overt hypothyroid) between the ages of 15-50 years from INMOL, Lahore and 60 healthy euthyroid controls of the similar age groups from local population were recruited. Additionally, follow up studies of nearly thirty five overt hypothyroid patients was also carried out after taking thyroxine for three months. Serum levels of fT4, fT3 and TSH were analyzed through Radioimmunoassay (RIA), whereas, levels of AST, ALT and creatinine were assessed using chemistry analyzer. Levels of ALT and AST were found significantly increased (P ≤ 0.05) in overt hypothyroid patients compared to controls and after treatment the concentrations of both enzymes were decreased non-significantly in post therapeutic group. Subclinical group also exhibited non-significant elevation in ALT and AST levels. Creatinine levels were significantly (P ≤ 0.05) increased in both subclinical and overt hypothyroid patients and mildly decreased in follow up group as compared to overt group. Conclusively, positive association of ALT, AST and creatinine with TSH and inverse relationship with fT3 and fT4 were observed in hypothyroid patients that reversed moderately after thyroxine therapy.
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