The Inhibition of Cell Proliferation of Bile Duct Scar Fibroblasts in Miniature Pigs by 5-fluorouracil and its Mechanism
The Inhibition of Cell Proliferation of Bile Duct Scar Fibroblasts in Miniature Pigs by 5-fluorouracil and its Mechanism
Shikang Deng1,2, Yan Jin2, Jing Xu2, Xiufang Zhu2, Pinghai Hu2, Jiao Li2, Li Zhang2 and Jianzhong Tang2,*
The effect of 5-FU on the OD value of bile duct scar fibroblasts in miniature pigs (n=3). Compared with group A, aP <0.05; compared with group B, bP <0.05; compared with group C, cP <0.05; and compared with group D, dP <0.05.
The effect of 5-FU on the expression levels of TGF-β1, cyclinD1, and CDK4 proteins in miniature pig bile duct scar fibroblasts (n=3).Compared with group A, aP <0.05; compared with group B, bP <0.05; compared with group C, cP <0.05; and compared with group D, dP <0.05.
The effect of 5-FU on the expression levels of TGF-β1, cyclinD1, and CDK4 mRNA in miniature pig bile duct scar fibroblasts (n=3). Compared with group A, aP <0.05; compared with group B, bP <0.05; compared with group C, cP <0.05; and compared with group D, dP <0.05.
