Regulation of Transforming Growth Factor-Alpha Expression by Thyroid Hormone during the Post-Natal Development of Rat Submandibular and Sublingual Salivary Glands
Regulation of Transforming Growth Factor-Alpha Expression by Thyroid Hormone during the Post-Natal Development of Rat Submandibular and Sublingual Salivary Glands
Shaher Bano1, Sarah Ghafoor1,* and Nadia Naseem2
ABSTRACT
Transforming Growth Factor-α is a mitogen peptide performing diverse cellular functions and is immunolocalized in ductal epithelium of salivary glands. The development of salivary glands is under the influence of various hormones including Triiodothyronine hormone (T3). Submandibular gland of rat is an excellent model to study salivary gland organogenesis. The study is designed to understand T3-mediated regulation of TGF-α expression during postnatal salivary gland development as it is currently unknown.Twelve male rats were taken at week three and twelve at week seven and divided into control and experimental groups. Control rats were given normal saline while experimental rats were given T3 at a dose of 1mg/kg body weight. All the animals were sacrificed on 15th day. Weight of each rat was calculated at the time of T3 administration. Body weight of experimental animals increased at a slow rate as compared to the control animals. The immunohistochemical expression of TGF-α in ductal epithelium of both salivary glands was decreased in experimental group sacrificed at 5 weeks. However no significant change was observed in TGF-α expression in ductal epithelium of salivary glands in rats sacrificed at 9 weeks.T3 has a temporal effect on TGF-α expression during early postnatal rat salivary gland development.
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April 2019
Vol. 51, Iss. 2, Pages 399-799
