Clinical Effect of GnRH-a and Gestrinone after Severe Endometriosis Operation: Randomized Clinical Trial
Clinical Effect of GnRH-a and Gestrinone after Severe Endometriosis Operation: Randomized Clinical Trial
Jialing Zhang1, Yan Ma2, Lili Lian3 and Min Wei1*
ABSTRACT
The objective of this study was to investigate the application effect of GnRH-a and gestrinone and nursing after severe endometriosis operation, looking at the long-term efficacy in preventing endometriosis recurrence and fertility outcomes. This study included 180 patients with severe endometriosis who were treated in our hospital. They were divided into the study group receiving GnRH-a treatment alone and the reference group receiving GnRH-a and gestrinone treatment. Patients in the reference group received routine nursing, while patients in the study group received comprehensive nursing intervention to compare the treatment outcomes of the two groups. Comparison of the two-year postoperative recurrence and pregnancy of the two groups showed no significant difference between the two groups, p>0.05. Moreover, the incidence of adverse reactions in the two groups showed a relatively higher irregular uterine bleeding rate in the reference group than in the study group, p < 0.05. When compared to sole GnRH-a, this is the first trial to indicate that adding gestrinone to the GnRH-a regimen resulted in significantly less irregular uterine bleeding while maintaining the same long-term effectiveness in avoiding endometriosis recurrence and benefits for fertility outcomes.
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