Potential of Protective Effect of Hydrated Sodium Calcium Aluminosilicate and Saccharomyces cerevisiae against Dietary Aflatoxicosis in Broiler Chicks
Potential of Protective Effect of Hydrated Sodium Calcium Aluminosilicate and Saccharomyces cerevisiae against Dietary Aflatoxicosis in Broiler Chicks
Reda Hassan*, Bahaa Abou-shehema, Sherif Zayed, Micheal Gorgy, Shama Morsy, El-Sayed Abu El-Hassan, Mahmoud El-Gbaly, Hanaa Basuony, Ebtehal Hassan
ABSTRACT
This study investigated the defensive effect of dietary Hydrated sodium calcium aluminosilicate (HSCAS) (0.5%) and Saccharomyces cerevisiae (SC) (0.1%) on the preclusion of aflatoxin-B1 (AFB1) toxicity in broiler chicken during 1 – 42 days of age. Eight hundred broiler chicks were arbitrarily assigned for 8 treatments of 5 replicates (each contained 20 chicks). On the other hand, chickens were offered the basal dietas Negative Control (NC, group 1); the other three groups 2, 3, and 4 were fed NC supplemented with 0.5% HSCAS, SC and HSCAS plus SC respectively, group 5 chicks were fed a basal diet contaminated with 1ppm AFB1 as Positive Control (PC), the other three groups 6, 7 and 8 were fed PC supplemented with 0.5% HSCAS, SC, and HSCAS plus SC respectively. Results exhibited that broiler chicks fed with a PC diet showed significantly (P<0.05) a worse feed conversion ratio and inferior daily body weight during the experimental period. Furthermore, AFB1 toxicity at 1mg dose significantly (P<0.05) increased creatinine, uric acid concentrations, alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities and significantly (P<0.05) reduced the antibody titer against sheep red blood cells (SRBC), total protein, albumin values in broilers serum compared with ngative control. Aflatoxins supplementation significantly (P<0.05) increased malondialdehyde values in liver and significantly (P<0.05) diminished the reduced glutathione (GSH), glutathione S- transferase (GST). In addition to, dissemination of aflatoxin residue in broilers liver was detected. Nevertheless, dietary addition of HSCAS and SC, in separate and combined forms, alleviated the above-mentioned alterations. The combination of HSCAS with SC was more efficient than having them in a separate form.
Keywords | Aflatoxin, Broiler, Adsorbent compounds, Detoxification
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