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Polymorphism in MCM6-Gene Associated with Lactose Non-Persistence in Pakistani Patients

Polymorphism in MCM6-Gene Associated with Lactose Non-Persistence in Pakistani Patients

Maria Qibtia1, Sehrish Faryal1, Muhammad Wasim1, Farzana Chowdhary1, Muhammad Tayyab1, Ahmed Mansovuri2, Zeeshan Ahmed2, Muhammad Hamid3 and Ali Raza Awan1,*

1Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, 54000 Lahore, Pakistan
2Max-Planck Institute for Biophysical Chemistry Molecular Cell Differentiation Group, Am Fassberg 11, 37077 Göttingen, Germany
3University of Ulm, Energiewandlung und-speicherung, Albert-Einstein-Allee 47, 89081 Ulm, Germany
 
* Corresponding author: arawan77@uvas.edu.pk

Fig. 1.

Genetic variations in MCM6-gene. The chromosome 2 with LCT and MCM6 gene (McIntosh and Scheinfeldt, 2012) is shown with two specific SNPs at intronic positions 13 and 9.

Fig. 2.

Chromatograms of SNP at INTRON 13 in the MCM6-gene. In mutant types A shows the partial heterozygosity with both alleles C/T. In mutant type B shows allele T in place of allele C. In wild type the actual gene with C allele is shown.

Fig. 3.

Chromatograms of SNP at INTRON 9 in theMCM6-Gene. In mutant type A shows the partial heterozygosity with both alleles G/A is shown. In mutant type B allele A in place of allele G is shown. C, in wild type the actual gene with G allele is shown.

Pakistan Journal of Zoology

December

Vol. 54, Iss. 6, Pages 2501-3000

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