Pasteurella Multocida: Composition, Genetics and Biosynthesis of Capsular Polysaccharides (CPS) of Serotypes A, B, D, E and F
Pasteurella Multocida: Composition, Genetics and Biosynthesis of Capsular Polysaccharides (CPS) of Serotypes A, B, D, E and F
Waqar Siddique1*, Sadia Mahboob1, Waqar Rauf1, Sobia Jabeen2, Zubera Naseem2, Fiza Shafaqat1
ABSTRACT
Pasteurella multocida is a gram negative bacterium and gaining importance due to its role in economic losses causing different diseases such as bovine hemorrhagic septicemia, swine atrophic rhinitis, avian fowl cholera etc. Capsular Polysaccharide (CPS) is one of the most important virulence factors that is currently highly being studied to use it as a vaccine candidate individually or as a conjugated vaccine with the immunogenic proteins. This review collects the latest data regarding the chemical composition, genetics and biosynthesis of CPS of all capsular serotypes (A, B, D, E and F) of P. multocida. These serotypes are primarily made up of hyaluronic acid, mannosaminuronic acid, heparosan, mannosaminuronic acid, and chondroitin respectively. The genes involved in CPS biosynthesis are divided into three regions (R1, 2, 3). Regions 1 encodes proteins to make ATP binding cassette transport system, Region 2 consists of the genes that encode for the synthases for the polymerization of serotype specific polysaccharides, Region 3 encodes proteins responsible for lipidation as well as surface attachment of polysaccharides. CPS is synthesized in majorly three steps; initiation of GAG (glycosaminoglycan) synthesis, extension of GAG disaccharide units and export of GAG. There is a further need to study the genetics and biosynthesis of CPS to use it as a successful vaccine candidate.
Keywords | Pasteurella multocida, Capsular polysaccharides (CPS), Virulence factors, Serotype, Hemorrhagic septicemia, Biosynthesis
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