Molecular Evaluation of Vp1 Coding Region of Foot and Mouth Disease Virus Circulating in Pakistan
Molecular Evaluation of Vp1 Coding Region of Foot and Mouth Disease Virus Circulating in Pakistan
Waqas Ali* and Mudasser Habib
ABSTRACT
Foot-and-mouth disease (FMD) is an extremely contagious viral disease of cloven-hoofed animals. In Pakistan, this disease causes huge losses to economy. However, the reports on its selection and evolutionary pathways are rare. In present study, 336 strains of serotype O (n = 178), A (n = 82) and Asia 1 (n = 76) were downloaded from NCBI database that mainly belonging to Pakistan, along with three vaccinal strains. Phylogenetic analysis (maximum likelihood) showed that lineages Pan Asia II, An Iran-05, and Group VII within serotype O, A and Asia 1 are causing majority of the outbreaks in the Pakistan during recent years. Moreover, only one residue of VP1 region was under positive selection pressure for serotype A (position 141) located in known critical antigenic region but as a whole protein was under negative selection pressure for serotype O, A and Asia 1. Therefore, under mass vaccination campaigns and drastic environmental conditions strains under negative selection has the ability to make escape mutants.
To share on other social networks, click on any share button. What are these?
