Immunohistochemical Analysis of P53 Gene Expression and other Protein Indicators in Chinese Hepatocellular Carcinoma Patients
Immunohistochemical Analysis of P53 Gene Expression and other Protein Indicators in Chinese Hepatocellular Carcinoma Patients
Huifen Li*
ABSTRACT
The objective of this study was to analysis P53 gene expression and other protein indicators in patients with hepatocellular carcinoma (HCC) in China. The present study collected a paraffin-embedded tissue sample of 31 patients with HCC from February 2021 to January 2022 from 13 pathology centers in Wuhu. The sample were stained using immunohistochemistry (IHC) method for detection of protein indicators. From the samples examined in this study, it was found that there are positive samples in P53 (n=8, 26.6 percent), RB1 (n=4, 13.3 percent), Cycline-D1 (n=6, 20 percent), c-Fos (n=14, 46.6 percent), and N-ras (n=3, 10 percent). In 85% of the sample, changes were observed in RB1 or Cycline-D1. The present study provides evidence that changes of P53 gene expression and other protein indicators play an important role in creating HCC.
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November 2024
Pakistan J. Zool., Vol. 56
