Submit or Track your Manuscript LOG-IN

Features and Prospect of Type V Secretion System in Bacteria

Features and Prospect of Type V Secretion System in Bacteria

Meng Wang, Dongliang Zhou, Huixia Li, Chunqin Wu,Yan Zhao and Houqiang Luo*

College of Animal Science, Wenzhou Vocational College of Science and Technology, Wenzhou 325006, People’s Republic of China

* Corresponding author:


Bacteria use a variety of mechanisms to transport proteins synthesized in the cytoplasm to the outer membrane or extracellular environment of the bacterial cell, or directly to other cells. The bacterial secretion system plays an irreplaceable role in this process. Up to now, at least 11 kinds of secretion systems are involved in the pathogenesis role of bacteria, especially the formation of bacterial resistance. Therefore, the study of the bacterial secretion system is of great significance for antibiotic treatment of bacterial diseases. Most of the secretion systems identified so far are found in Gram-negative bacteria. There are a few secretion systems in Gram-positive bacteria, such as type VII secretion system, which is found in Mycobacterium tuberculosis. T5SS may be the simplest secretion system available among all the secretion systems, and plays a vital role in the pathogenic mechanism of bacteria by participating in bacterial adhesion, biofilm formation, and contributing to the ability of nutrition acquisition a nd environme ntal adaptability. T5SS is a vital factor in the gradual reduction of antibiotic effectiveness, so the system has been the target of alternative antimicrobial strategies based on small molecules and antibodies. This review mainly introduces the discovery history of the bacterial secretion system, structure, and function of T5SS, and summarizes its potential applications and existing issues. Presently we have not elucidated the specific pathogenic mechanism of this system, thus the intensive study is significant.

To share on other social networks, click on any share button. What are these?

Pakistan Journal of Zoology


Vol. 55, Iss. 3, Pages 1003-1500


Click here for more

Subscribe Today

Receive free updates on new articles, opportunities and benefits

Subscribe Unsubscribe