Efficacy of Carica papaya Leaves Extract for Treating Thrombocytopenia: An In Silico and In Vivo Study in Rat Model
Efficacy of Carica papaya Leaves Extract for Treating Thrombocytopenia: An In Silico and In Vivo Study in Rat Model
Sony Eka Nugraha1*, Marianne Marianne2, Rony Abdi Syahputra2, Aji Najihudin3, Nikmatul Ikhrom Eka Jayani4, Shaum Shiyan5, Nabila Nabila6,7
Figure 1:
Gas chromatography/mass spectrometry (GC/MS) chromatograms
Figure 2:
(A) Platelet concentration; (B) Bleeding Time; (C) Thrombopoietin concentration . Asterisk *P ≤ 0.05, **P ≤ 0.01, *** P ≤ 0.001, ****P ≤ 0.0001 represents significant differences to heparin group and NS represents not significant (P > 0.05).
Figure 3:
(A) Prothrombin time; (B) APTT. Asterisk *P ≤ 0.05, **P ≤ 0.01, *** P ≤ 0.001, ****P ≤ 0.0001 represents significant differences to heparin group and NS represents not significant (P > 0.05).
Figure 4:
Docking visualization. A, Rutin-TpoR; B, Carpaine -TpoR; C, Manghaslin-TpoR; D, Clitorin- TpoR.
Table 1:
Ligand name.
July 2024
Vol. 12, Iss. 7, pp. 1206-1409
