Current Understanding and Future Perspective of Bats Antiviral Innate Immunity
Current Understanding and Future Perspective of Bats Antiviral Innate Immunity
King Hei Ip
Figure 1:
Structure of a virus. From: Taylor, 2010. CC0 1.0 Universal.
Figure 2:
Canonical IFN signalling cascade.
Figure 3:
Antiviral effector ISGs in bats. Adapted from: Zhang and Irving, 2023.
Figure 4:
The comparison of human and bat STING and inflammasome activities within a cell. The lost PYHIN gene family DNA sensor in bats leads to a dampened NLRP3-mediated inflammasome response, which also impacts the action of STING, which in bats lacks a serine residue, reducing its functionality (Clayton and Munir, 2020).
